The complexity of developing new healthcare technologies, compounded by the high uncertainty in radical innovation projects, necessitates a strategic approach to enhance project management and security. This paper proposes a practical harmonization framework for innovation in healthcare through the assessment of technology readiness levels (TRLs). Our work paves the way for more effective innovation assessments in emerging markets by bridging the gap between global TRL standards and local healthcare intricacies. We highlight previous efforts and limitations in implementing TRL adaptations in healthcare and introduce a novel tool designed to facilitate the evaluation of maturity levels within the Brazilian healthcare context by proposing a TRL framework tailored for the healthcare sector, focusing on integrating technical, regulatory, and intellectual property (IP) aspects. It serves as a guide for institutions looking to foster technology-driven advancements in healthcare, ensuring that innovations are groundbreaking and contextually relevant.