Conjunctival Tumors: Systemic Associations

Conjunctival tumors may be some of the prominent manifestations of systemic inherited diseases. In such instances, ophthalmologists should recognize the systemic association and initiate appropriate systemic and genetic evaluation. Conjunctival tumors and tumor-like conditions associated with systemic disorders can be categorized as pigmented lesions (Peutz–Jeghers syndrome), benign tumors (Goldenhar syndrome), malignant tumors (xeroderma pigmentosum), and amyloidosis. We present a review of this group of conjunctival lesions and their associated systemic disorders. Other entities may also have associated eyelid tumors and are covered in detail elsewhere. Where applicable, the genetic underpinnings of the syndromic association are discussed.