In this chapter I provide a hypothetical reconstruction of the dissemination of the handwritten copies of René[aut]Descartes, René Descartes’s Traité de l’homme up to the appearance of its first printed editions in 1662 (Latin) and 1664 (French). I discuss the manuscripts copied by Antonie Studler van Surck, Alphonse Pollot[aut]Pollot, Alphonse, and Elisabeth of Bohemia[aut]Elisabeth of Bohemia, its dissemination through the Socinian circles (including Henricus Regius’s access to it), and among the Leiden Cartesians (Adriaan Heereboord[aut]Heereboord, Adriaan, Johannes[aut]De Raey, Johannes de Raey[aut]De Raey, Elisabeth, and Aernout Huyberts[aut]Huyberts, Aernout). Moreover, I relate the manuscripts to the various attempts at securing and publishing manuscripts of L’homme (by the Elzeviers, Pierre-Hector Chanut, and Claude[aut]Clerselier, Claude Clerselier). On the ground of this reconstruction I provide a discussion of the handwritten translation of the treatise recently brought to the attention of scholars (ms. ATH 1444ms. ATH 1444), relating it to the efforts at making sense of the text by the Leiden Cartesians, and showing that it conveys a version of the treatise akin to the one published (1662) by Florentius[aut]Schuyl, Florentius Schuyl (with which it agrees in a number of substantial readings), while Clerselier might have published a text revised by Descartes around 1647.