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Retrograde trans-synaptic retinal degeneration may occur in patients with post-geniculate optic radiations lesions and can be showed in congenital/long standing homonymous hemianopia, acquired homonymous hemianopia and neurodegenerative diseases like multiple sclerosis or Alzheimer’s disease. This trans-synaptic retinal degeneration has been reported using spectral-domain optical coherence tomography (SD-OCT) of the macula, ganglion cell complex (GCC) and retinal nerve fiber layer (RNFL). OCT-angiography can also show decrease of vascular density in macular and peripapillary area.

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Trans-synaptic Retrograde Degeneration in the Visual Pathway in Central Nervous System Diseases

  • 章节

  • 发表日期：

    2025年

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  • Bernardo F. Sanchez-Dalmau,
  • Elena Brotons,
  • Anna Camos-Carreras,
  • Rafel Alcubierre,
  • Pablo Villoslada

摘要

Retrograde trans-synaptic retinal degeneration may occur in patients with post-geniculate optic radiations lesions and can be showed in congenital/long standing homonymous hemianopia, acquired homonymous hemianopia and neurodegenerative diseases like multiple sclerosis or Alzheimer’s disease. This trans-synaptic retinal degeneration has been reported using spectral-domain optical coherence tomography (SD-OCT) of the macula, ganglion cell complex (GCC) and retinal nerve fiber layer (RNFL). OCT-angiography can also show decrease of vascular density in macular and peripapillary area.