This study aims to present the evaluations, the role, and the distinguishing features of the activity performance of active economic enterprises that operate on a prefecture and regional basis. The turnover of the annual balance according to the economic activity is related to the size and the weight that they occupy, which affects the reduction of unemployment by encouraging the economic progress of the development of the region. The investigation of the differences encountered in the progress of economic and social development (as many distinctive phenomena are found in the structure of the employment rate according to the branches of the economy) enables the drawing of attention in the design of management strategies and visions. The selection of variables is aimed at studying the effects that influence the increase in the efficiency value of active economic enterprises. This paper presents a generalization of the aspects and value of the role of active enterprises in employment according to the branches of the economic structure and the improvement of the economic well-being of each prefecture. The study enables the recognition of best practices as well as inefficiencies in the performance value by applying the DEA method. The study extends to the period 2018–2022. This study presents an alternative to continuous and comprehensive managerial studies.