In this study, we investigate the thermo-hydraulic performance of a curved tube receiver integrated within a parabolic trough collector, leveraging state-of-the-art three-dimensional numerical simulations. Our primary objective is to evaluate and compare the efficacy of three prominent heat transfer fluids—namely, Syltherm 800, Therminol VP-1, and liquid sodium—in enhancing thermal energy conversion within the collector system. Central to our analysis is the inclusion of a meticulously engineered curved internal profile, strategically designed to amplify fluid turbulence and augment convective heat transfer at the fluid-tube receiver interface. Utilizing the sophisticated computational capabilities of the ANSYS-Fluent program and harnessing the predictive power of the RNG k-ε turbulence model, we execute a series of simulations to meticulously characterize the thermo-hydraulic behavior of the system under varying conditions. Through rigorous validation against established empirical and experimental data, we ensure the fidelity and reliability of our computational findings. By elucidating the intricate interplay between fluid dynamics, heat transfer mechanisms, and system geometry, our study aims to furnish invaluable insights for the optimization of tube receiver design and the judicious selection of heat transfer fluids in solar thermal applications.