This research explores the profound impact of Artificial Intelligence (AI) and machine learning (ML) on the sustainable transformation of the pharmaceutical industry. As the pharmaceutical sector undergoes significant technological advancements, the integration of AI and ML has emerged as a catalyst for innovation, efficiency, and eco-conscious practices. The abstract delves into the ways in which these technologies are reshaping drug discovery, clinical trials, and supply chain management, leading to more streamlined processes and enhanced sustainability. Through an analysis of case studies and industry practices, the study aims to uncover the specific contributions of AI and ML in reducing environmental impact, optimizing resource utilization, and promoting responsible practices within the pharmaceutical domain. By emphasizing the intersection of cutting-edge technologies and sustainability goals, this research aims to contribute valuable insights to the ongoing discourse on the transformative potential of AI and ML in fostering sustainable practices within the pharmaceutical industry.