In children with cerebral palsy (CP), prognosis regarding unaided walking, need for walking aids or wheelchair is possible at the age of 3 years. Gross motor function decreases in many adolescents and adults with CP due to pain, contractures, weight gain or burnout syndrome. Chronic diseases and behavioural and emotional problems are prevalent in adults with CP. Secondary musculoskeletal problems occur frequently. More than 90% of children with CP survive into adulthood. Life expectancy depends on GMFCS level and swallowing problems. Transition into those for adulthood remains difficult, especially for severely handicapped individuals. Health and social services are used less often by adults with CP. Health-related quality of life remains rather stable over the years; lower scores are found in severely affected persons. Participation strongly relates to the intellectual and social capacities of the individuals and may increase with improvements in rehabilitation technique, domestic assistance and legislation. This chapter is up to date in all historical fields.