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An innovative portable bioelectronic platform capable of multiplex detection, enabling simultaneous reading of multiple targets on a biosensor chip, has been developed. The platform utilizes Differential Impedance Sensing (DIS) with nanoparticle amplification. It features a sensor surface with 7 gold-interdigitated microelectrodes arranged differentially to minimize temperature and ion content fluctuations. This system facilitates simple adjustment of bio-probes for individual sensing sites, allowing for versatile detection of targets, ranging from DNA oligonucleotides to antigen-antibody complexes. This multiplexing diagnostic capability is essential for both current and future diagnostic instruments.

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Bio-reconfigurable Impedance-Based Platform for Multiplexing Diagnostic

  • 会议论文

  • 发表日期：

    2025年

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  • Arianna Adelaide Maurina,
  • Cainã de Oliveira Figares,
  • Francesco Damin,
  • Chiara Capelli,
  • Laura Sola,
  • Marcella Chiari,
  • Francesco Zanetto,
  • Giorgio Ferrari,
  • Marco Sampietro

摘要

An innovative portable bioelectronic platform capable of multiplex detection, enabling simultaneous reading of multiple targets on a biosensor chip, has been developed. The platform utilizes Differential Impedance Sensing (DIS) with nanoparticle amplification. It features a sensor surface with 7 gold-interdigitated microelectrodes arranged differentially to minimize temperature and ion content fluctuations. This system facilitates simple adjustment of bio-probes for individual sensing sites, allowing for versatile detection of targets, ranging from DNA oligonucleotides to antigen-antibody complexes. This multiplexing diagnostic capability is essential for both current and future diagnostic instruments.