The main emphasis of the study is family business performance in COVID-19. An analysis of Kabarole District, Uganda's many nuclei pattern. Data for the survey research design were gathered from both primary and secondary sources. We evaluated the effects of finance availability, business infrastructure, financial literacy, and corporate culture. Performance was measured using the following factors: family-run business, years of operation, profitability, and family dedication. Twenty (20) family-owned businesses that were situated in Uganda's Kabarole District throughout the period under review made up the study's population. The statistical package for social sciences (SPSS) software version twenty was used to analyze the data using the multiple regression strategy. The findings demonstrate that access to capital, such as grants, low-interest loans, and financial support from family members, has a major impact on performance. Performance was significantly impacted by business infrastructure (portable water supply, electricity, good roads, and succession planning), organizational culture (values, norms, and beliefs), and financial knowledge (application of basic accounting principles, report summaries, appropriate record keeping, and a skilled bookkeeper). Therefore, we recommended that the government create grants and low-interest loans to ensure family businesses have better access to funding. It is advised that family business owners and management develop a succession plan as soon as feasible, reduce the influence of family members on financial decisions, and use traditional accounting practices. The government's supply of sufficient infrastructure for enterprises, including reliable power, would lower operating costs and ensure the survival and success of family businesses in the COVID-19 age.