The National Health System of Spain (SNS) provides different structures and public services for the protection of health throughout the State, offering universal access to its services, which are financed through taxes. The opportunities in the field of Digital Health, and specifically in Digital Allergology are diverse and will be revised in this chapter. The SNS has large databases whose exploitation allows the generation of numerous indicators accounting for the current health situation. The development of a Digital Health Strategy (DHS) in Spain requires a prior review of the framework for digital transformation of the public administration as a whole and the need to adopt measures to address the problems of the manifest health system as a challenge. The new Spanish Strategy for Science, Technology, and Innovation, 2021–2027 constitutes a very good opportunity to achieve innovative operative goals. In this chapter, the reader will gain knowledge on reimbursement structures, mobile health developments, telemedicine and the utilization of digital health tools in the Spanish healthcare system.