As the healthcare landscape undergoes a digital revolution, new avenues are emerging for ensuring patient safety, fostering real-time clinical decision support, and enhancing personalized medical care. One area of significant impact is in the management of drug allergies. Drug allergies, potentially life-threatening responses to medications, present a ubiquitous challenge to clinicians and patients alike. Accurate diagnosis, documentation, and communication of these reactions are vital for preventing adverse events. Digital health, encompassing electronic health records (EHRs), mobile health (mHealth) applications, wearable technologies, and data analytics, is reshaping the way drug allergies are identified, documented, and managed. This chapter delves into the interplay between digital health solutions and drug allergy management, highlighting the advancements, current challenges, and the future trajectory of integrating technology to enhance patient safety and care quality. The intersection of digital health and drug allergies promises not only improved patient outcomes but also a paradigm shift in proactive and personalized allergy management.