This chapter analyzes the Single Minute Exchange of Die (SMED) lean manufacturing tool, delving into its concept, development, relevance, and the benefits it offers when well implemented. It also addresses the obstacles faced during its implementation. Moreover, it is crucial to consider specific fundamental measures throughout the implementation phase. Moreover, a bibliometric study is conducted to examine the prevalence of the SMED concept in the industry. This research specifically focuses on identifying the authors, institutions, and countries that contribute the most scholarly works or are most frequently cited. In conclusion, a case study demonstrates how the use of SMED can improve the company's capacity to manufacture items within the designated timeframe, leading to increased adaptability, reduced expenses, and enhanced product quality. The findings demonstrate that adopting the SMED methodology substantially increased the On-Time Delivery (OTD) metric, escalating from 91 to 98%. Furthermore, there was an approximate 55.55% decrease in the changeover durations. The company's problem was successfully handled by running a two-sample test using the SMED approach.