One of the pioneers of urban air mobility and new-generation aircraft is the emergency medical service (EMS) application. Thanks to the potential public benefit from the emergency operation, efforts to realize this vision are supported by both the relevant authorities and the general public. Even though the core electric powertrain technology is advancing at a rapid rate, the required performance for safe and sustainable EMS operations is still an open question. In this chapter, the requirements for an operational concept for Hungary were investigated. The goal was to determine whether today’s electric aircraft designs that potentially could be used as EMS vehicles can perform the missions with the current technology level, taking the current regulatory environment into account. The investigated vehicles are eVTOL (electric Vertical Take-off and Landing) aircraft concepts designed for urban air mobility (UAM) applications. Based on the analysis, the proposed 34 km operational radius concept is on the edge of feasibility, but it is very sensitive to the mission profile. The duration of the vertical climb and hovering is the most energy intensive, and the feasibility relies on keeping it short.