This article highlights the importance of transdisciplinary thinking in addressing complex problems and crises and explores the role of cross-cultural studies in promoting transdisciplinary thinking. As an example of such a cross-cultural study, this article presents a study conducted among Swiss and South Korean students, their perspectives, observations, and understandings of their own relationship with nature, as well as their ideas about how humanity might address the challenges of climate change, resource depletion, and biodiversity loss. This study shows that both cohorts have a strong sense of connection to nature, but for different reasons: Swiss students’ connectedness was based on a stronger physical experience and enjoyment of nature, whereas South Korean students’ connectedness was based on a stronger spiritual sense of identity with nature. Cultural variations were also found in students’ beliefs about who should take responsibility to make our ways of life more sustainable. The Swiss and South Korean cohorts differed in that they were either more inclined toward individual initiatives and role modeling or toward institutional changes that promote environmentally friendly practices and policies. In this sense, this comparative study has revealed the importance of variation when dealing with cultural differences. Using this cross-cultural study as an exemplary case, this article argues that cross-cultural studies can serve as a valuable approach to transdisciplinary thinking because they inherently integrate different observations, understandings, and methods of adaptation, fostering multiperspectivity and a greater variety of possible solutions to the complex challenges we face in the 21st century.