错误:搜索内容不能为空,请输入英文关键词
错误:关键词超出字数限制,请精简
高级检索

The Acute Toxicity of a New Feed Additive for Poultry Based on the Biometal: Chromium

  • Olga Sevostyanova,
  • Valeria Shakhova,
  • Ivan Kireev,
  • Elena Kastornova

摘要

Poultry farming is a world leading industry in the production and consumption of meat products. The issue of developing effective tools remains relevant according to the intensive technological cycles and inevitable stressful stimuli, and the need to obtain high-quality products that meet safety standards. In this regard our research particular interest is the design and preclinical examination of chemotherapeutic agents that are not aggressive stimulants. Such agents include nutrient-based feed additives that supplement the basic diet of poultry. The research team has developed a feed additive based on chromium biometallic and amino acid complex. This article presents the results of the toxicological examination of the developed drug, namely acute toxicity. The objects of the study were white nonlinear mice, white nonlinear rats, and broiler chickens. During the experiment, it was not possible to establish the average lethal dose of the feed additive. The use of the supplement at doses of 4000, 4500, 5000 and 5500 mg/mg of body weight showed no signs of toxic effects. The data obtained make it possible to classify the developed additive to hazard class 4, that is, low-hazard substances, and also allow us to talk about a significant range of toxicological harmlessness. The information obtained empirically allows us to assert the prospects for further study of the developed chemotherapeutic agent.