The Government of Ghana, in dealing with COVID-19, implemented various public health and financial packages to mitigate the impact of the pandemic, among lower socio-economic groups and small and medium scale enterprises. This study is an ethnographic assessment of the extent to which measures were successfully implemented in the Makola Marketplace place in Ghana. We qualitatively assessed 6 anti-COVID-19 measures, using a combination of desk reviews, key informant interviews, and direct observation of the Makola Market in Accra, Ghana. The measures assessed were practices around 1. health promotion, 2. infection prevention control, 3. social distancing, 4. mask-wearing, 5. knowledge and attitudes to COVID-19 vaccines, and 6. nature of and response to financial mitigation measures from government. We recommend that the current close collaboration between local authorities and market women in the development and rollout of public health interventions should be complemented with real-time joint monitoring to effect necessary adaptations to new realities and misinformation. We also recommend the development of an adapted market vulnerability index for proactive planning, rapid resource allocation, and advocacy for policymakers and local government officials. Finally, we recommend simplifying application processes to help facilitate access to loans and financial assistance packages by market women.