Improving Continuous Monte Carlo Tree Search for Identifying Parameters in Hybrid Gene Regulatory Networks

Monte-Carlo Tree Search (MCTS) is largely responsible for the improvement not only of many computer games, including Go and General Game Playing (GPP), but also of real-world continuous Markov decision process problems. MCTS initially uses the Upper Confidence bounds applied to Trees (UCT), but the Rapid Action Value Estimation (RAVE) heuristic has rapidly taken over in the discrete and continuous domains. Recently, generalized RAVE (GRAVE) outperformed such heuristics in the discrete domain. This paper is concerned with extending the GRAVE heuristic to continuous action and state spaces (cGRAVE). To enhance its performance, we suggest an action decomposition strategy to break down multidimensional actions into multiple unidimensional actions, and we propose a selective policy based on constraints that bias the playouts and select promising actions in the search tree. The approach is experimentally validated on a real-world biological problem: the goal is to identify the continuous parameters of gene regulatory networks (GRNs).