Immune-Mediated Necrotizing Myopathy
摘要
Immune-mediated necrotizing myopathy (IMNM) is the youngest subgroup within the idiopathic inflammatory myopathies, described by the European Neuromuscular Centre in 2004. Patients with IMNM clinically present significant proximal muscle weakness, along with markedly elevated creatine kinase levels, while extra-muscular manifestations are rare. Moreover, this disorder is characterized by the presence of fiber necrosis and minimal inflammatory infiltrate in the muscle biopsy. Three distinct subtypes of IMNM have been recognized: associated with anti-SRP antibody, associated with anti-HMGCR antibody, and seronegative IMNM.