Acid-Related Disorders

There are three main groups of acid suppressant drugs containing antacids, histamine H2 receptor antagonists, and proton pump inhibitors. Their role is to elevate gastric pH through different mechanisms and with different duration of action, from short-acting antacids to PPI which have the longest duration of acid suppression. Other drugs used for treating acid-related disorders also include sucralfate, bismuth, and prostaglandin analogues. All of them can interact with other drugs affecting their absorption, metabolism, and elimination. As gastric acid-reducing agents are commonly used to treat conditions pertaining to gastrointestinal disease in all age groups, we will review possible interactions with the most common orally administered medications taking into consideration potential comorbidities we can expect in our everyday practices.