Comorbidity and Comedication in Irritable Bowel Syndrome Patients

Irritable bowel syndrome(IBS) is one of the most common disturbances in the gastrointestinal tract, referring to visit a gastroenterologist, internist, and general practitioner. Unfortunately, this condition is accompanied by other co-occurring and additional conditions, which compilate diagnostic procedures, follow-up of such patients, and raise the diagnostic procedures costs and medication costs. The IBS diagnostical procedure is performed according to Rome IV criteria. The standard therapy depends on the IBS form but usually consists of a fiber diet, probiotics, spasmolytic, prokinetics, laxatives, and other therapies. Comorbidity in IBS has etiology and pathophysiology processes, that cross pathophysiology ways with IBS including microbiota, inflammatory processes, immunology processes, brain-gut axis, and genetic and epigenetic changes. All of these changes and processes have an influence on the development of IBS complications and comorbidity in IBS patients. All of these include gastrointestinal comorbidity (gastroesophageal reflux disease, functional dyspepsia, etc.) and extraintestinal comorbidity including locomotor, psychological, psychiatry, urological, gynaecological, and a lot of other disturbances, which are diagnosed according to the procedures founded for these clinical pathology conditions. Some models of therapy for IBS and medication forms for this comorbidity condition have a lot of touching points between each other.