Today, the role of the construction sector is fundamental to mitigating climate change, especially given the potential of innovations introduced during the Industrial Revolution. The Internet of Things (IoT), together with Internet-enabling technologies, has developed and spread even in the architecture, engineering, and construction (AEC) sector, though with some differences in purposes and objectives. However, especially in the field of heritage buildings, a gap in the definition of cultural heritage (CH) and the one in the concept of smartness need to be bridged. This chapter aims to identify specific innovative approaches for CH, through an analysis of a literature review and best practices related to the different applications of the aforementioned technologies, to develop a roadmap toward new perspectives against climate change while increasing the smartness of the heritage environment.