The presented research study investigates the structural behaviour and performance of a hybrid timber–concrete floor system. These hybrid systems have been proven to contribute to the reduction of the carbon footprint during the construction of a building. In the current paper, a series of numerical analysis have been conducted. A reference numerical model has been created based on a test specimen from the international literature, and the test results have been used for the calibration and validation of the numerical model. The hybrid floor system consists of a set of glulam beams that are connected to a concrete slab. The flexural strength and the deflection of the system under a four-point bending test configuration have been determined. Moreover, several parameters of the system such as the thickness of the concrete slab, the strength class of the glulam beams, and changing the load placement are further investigated to provide a better insight into the response of the system under examination. The numerical results have been assessed and depict that hybrid timber–concrete systems are a sustainable and efficient alternative to traditional steel-concrete floor systems.