Different computational approaches to predict aircraft loads and aeroelastic responses based on industry-relevant demonstration examples are presented. To reduce computational efforts, methods to establish a structural reduced-order model and its applicability for flexible aircraft configurations are studied. To gain a better understanding of the underlying flight physics, higher-order aeroelastic modelling approaches are used through coupled CFD-CSM techniques. Lastly, the impact of nonlinearities owing to large deformations on the prediction accuracy when using state-of-the-art flutter prediction methods is analysed.