Alcohol, tobacco, and firearm use are the root causes of disability and mortality in the United States. The use of these products in adolescence has considerable impacts on immediate and lifelong health. Adolescents have been the key targets of alcohol, tobacco, and firearm companies because of the potential to shape brand alliances and lifetime use. Marketing and product placements in media have often been used to reach the adolescent market for tobacco and alcohol products, continue to be used to reach the adolescent market for alcohol, and emerging data suggest that they may be used to reach the adolescent market for firearms as well. This chapter discusses how these products are marketed to adolescents using contemporary digital media, including social media, the metaverse, and video games. This chapter illustrates the marketing tactics used in these spaces and discusses the current research gaps that limit our understanding of a causal association between digital marketing exposures and adolescent product use. This chapter closes with recommendations for future efforts to protect adolescents from marketing by companies that produce harmful products.