Determination of Neuronal Activity and Its Meaning for the Processes of Learning and Memory

Despite the years of studies in the field of systems neuroscience, the functions of neural circuits and behavior-related systems are still not entirely understood. The systems description of brain activity has recently been associated with cognitive concepts, e.g., a cognitive map, reconstructed via place-cell activity analysis and the like, and a cognitive schema, modeled in consolidation research. The issue we find of importance is that cognitive concepts reconstructed in neuroscience research are mainly formulated in terms of the environment. In this chapter, we present the idea of an element of individual experience that serves as a model of behavioral interaction with the environment, rather than a model of the environment itself. This intangible difference entails the need for substantial revision of several well-known phenomena, including long-term potentiation. The principal questions we address are: how do elements of experience appear and change during learning and performance; and how do the links between these elements create the whole structure of individual experience? We argue that learning and memory research need a clear distinction between processes that provide the emergence of new elements of experience (functional systems) and processes underlying the retrieval and/or changes in the existing experience. We propose to view the activity of a neuron as an “action” directed to the future adaptive “microresult,” essential for meeting its metabolic needs. This anticipatory neuronal activity is coordinated with the activity of many other cells of the body in the organism-wide functional system, ensuring the achievement of an adaptive “macroresult” at the behavioral level. From this perspective, the mechanisms of learning are considered as the formation of functional systems, and memory is considered as a dynamic structure constituted by systems formed at different stages of individual development.