Role of Diffusivity of Lactate on Its Accumulation in Tumor Necrotic Core

Tumors are heterogeneous composition of cells having different diffusivity. The necrotic core is commonly seen even in small tumors. It has different material properties compared to other components of the tumor. The necrotic core poses a challenge for diffusion. Due to glycolysis metabolic process, tumor cells in hypoxic region generate lactate in greater amount. In this study, using a mathematical model, we explore the effects of diffusivity hindering the property of the necrotic core in the tumor on lactate accumulation over the tumor region. Our results are consistent with experimental observations.