Fungal disease control in grapevine is essential for the production of high-quality grapes. Regardless of the strategies and modes of production implemented (organic, biodynamic, integrated) and whatever the climatic conditions, growing sensitive Vitis vinifera cultivars depends on the success of disease control. Since the arrival of downy and powdery mildew in Europe over 150 years ago, no alternative to spraying the vines with fungicide at regular intervals has been found. Active ingredients in the fungicides were based on copper and sulphur until the development of newly synthesised molecules in the late 1950s, followed by the release onto the market of several plant protection products. Their regular use raises environmental and human health issues for scientists and practitioners, still searching for more natural and effective alternatives. Despite major research efforts on this front, even naturally occurring molecules used as plant protection products must be applied precisely on the leaves and grape surfaces, requiring the right product, the right dosage and the right timing of the application depending on the biological development of the pathogens and sensitivity of the vine. Success also ultimately depends on the technical performance of the sprayer and its calibration to guarantee efficacy, as well as the protection of the environment and the user.