Multiple Myeloma

Multiple myeloma accounts for about 10% of hematologic malignancies. It is one of the most intractable malignancies and is characterized by the presence of neoplastic terminally differentiated immunoglobulin-producing B lymphocytes (plasma cells) that depend on the bone marrow microenvironment for growth and survival. Thus, multiple myeloma is characterized by infiltration and growth of malignant plasma cells in the bone marrow accompanied by osteolytic lesions and fractures of the affected bones (Furukawa and Kikuchi 2015; Cheng et al. 2021; Rajkumar 2022). Thus, the bone marrow microenvironment plays an essential role in the development and progression of multiple myeloma (Kawano et al. 2015). As mentioned above, nerve fibers are also an important component of it. Thus, these fibers form the link between the nervous system and the myeloma.