This chapter delves into the growing field of mobile anesthesia and sedation, a practice in which a mobile anesthesia provider transforms an outpatient clinic into an environment where anesthesia care is delivered on par with care received in traditional settings. It begins by tracing the historical evolution of mobile anesthesia from “field anesthesia” in wartime to the present day, highlighting technological advancements that have facilitated this growth. The chapter then discusses the benefits of mobile anesthesia, such as increased accessibility, cost-effectiveness, and patient comfort, while also addressing the specific challenges and limitations inherent to delivering care outside conventional medical facilities. A detailed exploration of the mobile anesthesia setup, including equipment, facility requirements, and provider training, provides a comprehensive understanding of the essential operational aspects and safety protocols. The chapter offers valuable insights into the complexities, advantages, and considerations of mobile anesthesia and sedation, as well as its role in expanding the reach and efficiency of modern anesthesiology practices.