Nephron Senescence and Mechanisms

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发表日期：

2024年

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Helen Healy,
Andrew J. Kassianos,
Monica S. Y. Ng,
Eoin D. O’Sullivan

摘要

Kidney aging is the loss of tissue and organ function over time. Cellular senescence is a state of permanent growth arrest and cessation of cell division. Although aging and senescence share some features, the two processes differ. In contrast to aging, senescence occurs when a cell irreversibly exits the cell cycle and assumes a distinct phenotype. This chapter on nephron senescence and mechanisms explores the proposition that senescence in the kidney is more than just normal organ aging but instead encompasses pathobiological pathways that are activated by injury and result in pathologic alterations in kidney tissue and function. We discuss the role of cellular senescence in a variety of kidney diseases and consider the potential therapeutic benefits of targeting senescent cells in diseased and aged kidneys.