Indication for Biopsy: Renal Allograft

Most renal allograft biopsies are done because of impaired excretory function, called graft dysfunctionGraft dysfunction. The two common problems for a pathologist are to decide whether there is significantlyRenal allograftsignificant acute cellular rejection active, acute rejection, that may respond to treatment, and whether there is chronic damageRenal allograftchronic damage, that will not respond to treatment. There are fiveRejectionacute cellular rejection diagnoses related to acute rejectionAcute rejectionacute cellular rejection. TheseRejectionantibody mediated rejection areRejectionsevere acute vascular rejection acute antibody mediatedRejectionacute vascular rejection rejectionAcute rejectionantibody mediated rejection, significantAllograft, kidneyacute cellular rejection acute cellular rejectionAcute rejectionsignificant acute cellular rejection, acute vascular rejectionAcute rejectionacute vascular rejection, severe acute vascular rejectionAcute rejectionsevere acute vascular rejection, andRejectionsignificant acute cellular rejection noSevere acute vascular rejection evidenceTransplantation, kidneyacute cellular rejection ofTransplantation, kidneysevere acute vascular rejection significant acute rejection. Late damage in an allograft, meaning tubular atrophyTubular atrophy in particular, may resultTransplantation. kidneychronic rejection fromChronic rejection chronic rejectionAllograft, kidneychronic rejection, butRejectionchronic rejection there are several other possible explanations. Other disorders that may occur in grafts include glomerular abnormalities that may be due to a variety of causes, vascular and ureteric problems, infections, and neoplasms.