Neurocognitive Changes
摘要
The majority of patients with brain tumors experience cognitive dysfunction, frequently at presentation, and often worsening over time. The potential cognitive effects of systemic cancer therapy and the cancer process itself are also recognized in non-CNS tumors. Although there are strategies to minimize the cognitive burden for patients, including for those with intracranial disease undergoing radiotherapy, there are few effective treatments for cognitive impairments once they develop. Therefore, when making clinical decisions in cancer care, it is imperative to consider cognitive risks and benefits associated with specific interventions. To better aid in this decision-making process, this chapter reviews cancer-related cognitive effects, impact of different systemic therapeutic modalities with CNS involvement and intracranial radiation, mitigating strategies, and the assessment of cognitive function.