A significant element of an UAS system is the ground station, which is the man–machine interface with the unmanned aerial vehicle. Depending upon range and type of mission (complexity of the UAV system), smaller UAVs are controlled via visual contact (manual real-time control), while the larger ones are equipped with a communication system (to control beyond line of sight). This chapter will introduce features of ground station, main elements, and support equipment, and design requirement. Since a human is utilizing the station, the ergonomics is briefly reviewed.