Target Volume Delineation for Plasmacytoma and Multiple Myeloma

Solitary plasmacytoma and multiple myeloma are plasma cell neoplasms arising from mature B-cell monoclonal populations. Patients with solitary plasmacytoma are treated with definitive radiation therapy to address local disease. While systemic therapy is the mainstay for the treatment of multiple myeloma, palliative radiation therapy can offer clinical benefit in situations of cord compression, refractory pain, and impending fracture. Herein, we review the target volumes utilized for the treatment of solitary plasmacytoma and multiple myeloma with radiation therapy.