Methadone

MethadoneMethadone is a synthetic, long-acting opioidOpioids, with parenteral and oral routes of administration. It is commonly used by physicians for treatment of opioidOpioids dependency, perioperative pain managementPerioperative pain management, and chronic painChronic pain. Synthesized during World War II to relieve shortages of morphine, methadoneMethadone was introduced into the United States in 1947.(1) Its early use was noted in the treatment of opioidOpioids withdrawal and maintenance therapy for opioid dependenceOpioid dependence.