Injectable Hydrogel Composites for Biomedical Applications Based on Nanostructured Biogenic Hydroxyapatite and Sodium Alginate
摘要
In this work, hydrogel composites based on sodium alginate (AlgNa) and biogenic hydroxyapatite (BHA) were obtained by physical crosslinking followed by lyophilization. BHA in amounts of 1, 2, 3 and 10 wt% was used for mineralization of AlgNa hydrogel and composites preparation. XRD, FTIR, TGA, SEM, helium pycnometry as well as swelling study were utilized to characterize structure and properties of AlgNa hydrogel and AlgNa/BHA composites. It was established hydroxyapatite incorporation into covalently cross-linked sodium alginate hydrogel and formation of porous composites with complex specific reliefs and with distribution of nanostructured biogenic hydroxyapatite particles both throughout the hydrogel volume and on its surface. It was found that equilibrium swelling degree of AlgNa hydrogel and AlgNa/BHA composites achieves during first 4 h. Moreover, increasing BHA content up to 10% leads to reduce swelling degree by 30–40 times.