Polymer Hydrogels Based on PAA as Matrices for the Controlled Release of Bioactive Molecules

Cross-linked PAA hydrogels containing polymer fragments with ionizable cationic/anionic functional groups were synthesized as model matrices to study their ability to absorb and release ionic dyes. Hydrogels were synthesized by graft copolymerization of acrylamide on chitosan, dextran, and dextran sodium sulfate with simultaneous cross-linking using N,N-methylene-bis-acrylamide. Study of swelling kinetics and absorption–desorption of acid fuchsin, basic fuchsin and neutral red as drug models to assess the transport of bioactive molecules by synthesized gels was carried out.