Hydrometallurgical processes necessitate robust materials capable of withstanding corrosive environments. This study evaluates the corrosion behavior of 2205 duplex stainless steel (DSS) using a two-level factorial design in simulated hydrometallurgical conditions. Factors including sulfuric acid concentration, Fe(III)/Fe(II) ratio, copper concentration, and temperature are investigated for their impact on the uniform corrosion rate of the alloy. Temperature, Fe(III)/Fe(II) ratio, and sulfuric acid concentration are individually significant for corrosion rates. The temperature/sulfuric acid and Fe(III)/Fe(II) ratio/temperature interactions were also found to be significant. Despite the various aggressive conditions, 2205 DSS had corrosion rates below 0.1 mm/year. Moreover, the alloy exhibits robust resistance to localized corrosion with critical pitting and crevice corrosion temperatures exceeding 95 °C, suggesting its suitability for hydrometallurgical applications.