As time progresses, more copper deposits with higher arsenic are exploited leading to higher arsenic in concentrates delivered to copper smelters. Arsenic is often associated with antimony; hence, it is judicious to develop refining processes that consider both. Copper electro-refineries can process copper anodes containing up to 2000 ppm of arsenic, higher levels potentially impacting the process. This paper discusses the use of conventional fluxes (Na2CO3 and CaO) for the control of As and Sb in anode copper. The behavior of other minor elements is also discussed (Ni, Bi, Pb, Se, and Te). Major factors affecting As and Sb elimination efficiencies are reviewed (flux addition, %CaO/%Na2CO3 ratio, and oxygen content in blister copper). Mechanisms for refractory corrosion are also reviewed as well as slag recycling practices. Using the Factsage software and available thermodynamic databases, process maps were prepared portraying operating windows, arsenic and antimony in anode copper and saturation lines.