Anode slime is the by-product of copper electrorefining and contains precious metals, crucial for several industries, such as automobiles, petroleum, chemicals, electronics, glass manufacturing, and medical implants. Considering our materials-intensive future, alongside the imperative to prioritize green technologies, and transition from a linear economy to a circular economy, a focus on optimization of multi-metal recovery such as that of precious metals in copper flowsheets is increasingly necessary. Copper anode slime undergoes different treatments, including pyrometallurgy, hydrometallurgy, and hybrid processes, to recover these elements. The slime’s composition and phases, type of treatment, and choice of technology affect the metal recovery rate. This work aims to provide a state-of-the-art overview of slime treatments and technologies envisioning optimized resource recovery and fostering sustainable practices in metal production.