In copper electrowinning (Cu-EW) process, lead alloy anodes have been the widespread reference for oxygen evolution reaction (OER). On the other hand, Mixed Metal Oxide anodes (titanium substrate plus coating for OER) are considered as an alternative enabling power saving and removal of lead sludges and eliminating the need for cobalt addition. Normally, Cu-EW solution contains mainly copper sulfate and sulfuric acid, and durability and activity are required to anodes. In this context, De Nora has been working on development of a coating for MMO anodes for Cu-EW and verified a multi-year operation under laboratory test using a real plant solution. A developed coating was integrated into De Nora DSA® Self-protective Anode, which can withstand short circuit conditions with no damage to the anode by limiting the current flow on the short circuit. De Nora DSA® Self-protective anodes have been supplied to electrowinning plants for operation in Cu-EW customers’ conditions for industrial testing and validation, and successful operation for more than 50 months has been confirmed at a specific customer.