Marine structures, including ships and offshore facilities, constantly face environmental challenges such as saltwater exposure, biofouling, and temperature fluctuations. Biofouling, the accumulation of aquatic organisms on these structures, elevates ship hull weight and roughness, resulting in high frictional resistance and increased fuel consumption. Moreover, it causes corrosion in metal structures, posing potential risks to marine equipment integrity and safety. The inadvertent release of biofouling organisms during cleaning or relocation of submerged structures further threatens human health, the aquatic environment, and socioeconomic values. Addressing this, the urgent development of eco-friendly coatings to prevent and manage biofouling is imperative. This research aims to pioneer anti-biofouling coatings through cold spray technology. Leveraging high-entropy alloys (HEA), these coatings will either inherently possess antifouling properties or serve as matrices for doped antifouling agents. Specifically, this study focuses on exploring cold spray of CoCrFeMnNi (cantor alloy) combined with varying copper weight ratios. The link that displays between process-structure-property-performance in these coatings will be explored and applied for materials and design. The outcome of the proposed research will make marine operations less energy-intensive, safer, and less costly, protect marine life, and will contribute to the blue economy.