Molecularly imprinted polymers (MIPs) have recently proven to present excellent solutions in analytical and biological applications. However, issues such as lack of conductivity, low electrocatalytic activity, and, slow mass transfer, have restricted the utilization of MIPs in various fields. The incorporation of diverse functional smart materials into the molecular imprinting procedure is a promising strategy for designing new functional tools carrying advantages of both smart materials and MIPs. Currently, numerous smart materials such as gold and silver nanoparticles, magnetic nanoparticles, quantum dots, carbon dots, graphene, etc. are being integrated into MIPs for various applications including cell imaging, sensing, environmental monitoring, and medical research. These smart nanomaterials possessing outstanding properties such as distinctive electrical, mechanical, catalytic, optical, and magnetic properties with good dispersion capacity and large surface-to-volume ratios have the potential to be successfully used in combination with MIP for highly selective detection systems. This chapter focuses on integrating organic, inorganic, and hybrid smart materials with molecular imprinting technology and introduces their combined applications across various fields.