JAK Inhibitors as Immunomodulators

The dermatologist must focus on the mechanisms of action of the Janus Kinase pathways and the pathogenesis of cytokineCytokine production from lymphocytes and transcription of other effector cytokines. The clinical relevance to dermatologists including the impact on inflammationInflammation and pathogenesis of diseases such as atopic dermatitis, psoriasisPsoriasis, vitiligo, and other conditions including clinical trial data, topical and systemic therapies, and future medications in development will also be reviewed. A general overview of the efficacy and safety in context to the background behind black box warnings should serve to alleviate concerns for the practicing dermatologist on their incorporation into the therapeutic toolbox.