Parkinson’s diseaseParkinson´s disease (PD) is the second most common neurodegenerative diseaseNeurodegenerative disease. The majority of PD patients presented an idiopathic disease (IPD), whereas a small subgroup showed a geneticGenetic form. At present, the IPD diagnosisDiagnosis is largely based on clinical criteria. Due to the imperfect sensitivity and specificity, a combination of diagnostic tests has been proposed to achieve an acceptable sensitivity and specificity for the PD diagnosis. This chapter is focused on analyzing skin biopsySkin biopsy as new biomarkerBiomarkers for PD. SkinSkin biopsy represents a promising diagnostic tool for PD and other synucleinopathiesSynucleinopathies also suitable for the in vivo study of pathogenetic mechanisms correlated to misfolded α-syn deposition in neurons.