The skinSkin is the largest organ of the human body and provides a barrier between the internal environment and stressors from the external environment, including ultraviolet radiation (UVR), pollution and harmful microorganisms. MitochondriaMitochondria are known as the powerhouse of the cell due to their role in cellular energy production through the generation of adenosine triphosphate (ATP). They possess their own maternally inherited genome (mtDNA) which encodes 37 genes and is considered vulnerable to damage and mutationsMutations due to its close proximity to the site of energy production and therefore reactive oxygen speciesReactive oxygen species (ROS). Mitochondria have vital roles within the skin including energy generation, maintaining homeostasis and growth. Research suggests that mitochondrial dysfunction through mtDNA damage is associated with skinSkin disorders such as skin agingSkin ageing, skin cancerSkin cancer and other diseases, and studies have identified mtDNA biomarkersBiomarkers in such skin disorders.