Autophagy and Reactive Oxygen Species in Cancer: An Introduction

Autophagy is a fundamental process that plays a critical role in maintaining cellular homeostasis by orchestrating the degradation and recycling of damaged organelles and proteins. ROS are vital in various cellular processes, including proliferation, differentiation, and apoptosis. In cancer, dysregulated autophagy and aberrant ROS levels have become crucial factors influencing tumorigenesis and progression. This book chapter explores the intricate relationship between autophagy and ROS in cancer biology. It begins by explaining the mechanistic underpinnings of autophagy, detailing its regulatory pathways and physiological significance. Additionally, it examines the diverse sources of ROS within the cellular environment and their implications for cancer development. Furthermore, it delves into the intertwined pathways linking autophagy and ROS in cancer. It explores pathways that intricately connect autophagy and ROS in the context of cancer pathogenesis, shedding light on potential therapeutic targets and biomarkers.