Probiotics as Next-Generation Mucosal Vaccine Vectors
摘要
The vaccine is purposed to strengthen the adaptive immune system by means of specific antigens or immunogens. Mucosal administration of protein antigens is an effective and preferred method for induction of tolerance against diseases. Degradation of orally administered protein antigens by gastric enzymes impedes the antigen efficiency, thus increasing the cost of treatments based on protein antigens. The limitation can be overcome by tolerogenic bacterial delivery of the antigens. Recombinant probiotics are the emerging therapeutics and vehicles to deliver antigens through mucosal routes as immune responses at mucosal sites serve as the first line of defense against incursive pathogens.