The Human Microbiome as Source of Therapeutics
摘要
The high metabolic capabilities of the human microbiota make it a treasured source of metabolites and bioactive therapeutic capabilities. Short-chain fatty acids (SCFAs), antimicrobial proteins and peptides (AMPs), and bacteriocins and neurotransmittersNeurotransmitters confer multiple health benefits. Some metabolites interfere at various cellular and molecular levels and influence the initiation, promotion, and progression of noninfectious diseases such as colon cancer. Gut metabolites of dietary phytochemicals have multiple roles as antioxidants, anticarcinogenic, and health promoters. Dietary manipulation aims to modulate gut microbial metabolites in diverse pathways. Information delineated here has implications to develop therapeutics that could steer functioning of GI ecosystem to boost host’s nutritional and immunomodulatory efficacy.